We Use CookiesWe use cookies to enhance the security, performance,
functionality and for analytical and promotional activities. By continuing to browse this site you
are agreeing to our privacy policy
10 Best Pain Relief Creams 2025 in the United States
#1
Winner
Biofreeze Professional Pain Relief Roll On, Knee & Lower Back Pain Relief, Arthritis Pain Reliever, Neck Pain Relief, Cooling Joint Pain Relief, Roll-On Menthol Gel 3 Fl Oz (Pack of 3)
The Biofreeze Professional Menthol Roll-On Pain-Relieving Gel is designed for effective and convenient pain relief. It's popular among various healthcare professionals for its fast-acting and long-lasting relief, making it ideal for minor aches and pains like backaches, strains, bruises, and sprains. The roll-on application method is particularly user-friendly as it offers a mess-free and hands-free experience, which is great for those who need pain relief on-the-go.
Customer Highlights
A summary of real customer reviews to highlight what shoppers are saying!Customer Highlights
A summary of real customer reviews to highlight what shoppers are saying!#2
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief - NEW Easy Open Cap - 150 g
The Voltaren Arthritis Pain Gel is designed for individuals seeking relief from arthritis pain. It contains a nonsteroidal anti-inflammatory drug (NSAID) that tackles inflammation directly at its source. This makes it effective for reducing stiffness, improving mobility, and providing significant pain relief, particularly for conditions like hand, wrist, elbow, ankle, foot, and knee pain.
Customer Highlights
A summary of real customer reviews to highlight what shoppers are saying!Customer Highlights
A summary of real customer reviews to highlight what shoppers are saying!#3
Biofreeze Pain Relief Cream, Knee & Lower Back Pain Relief, Sore Muscle Relief, Neck Pain Relief, Shoulder Pain Relief, Muscle Recovery, FSA Eligible, 3 OZ Biofreeze Menthol Cream
Biofreeze Pain Relief Cream stands out as a trusted option for those seeking relief from various types of pain, including knee, lower back, sore muscles, neck, and shoulder pain. One of its strongest points is the use of menthol as the active ingredient, which is known for its fast-acting, cooling effect that can penetrate deep into muscles and joints to alleviate discomfort. This makes it ideal for minor aches, arthritis, and injuries like strains and sprains.
Customer Highlights
A summary of real customer reviews to highlight what shoppers are saying!Customer Highlights
A summary of real customer reviews to highlight what shoppers are saying!Top 10 Best Pain Relief Creams 2025 in the United States
#1
Winner
9.8 score
Biofreeze Professional Pain Relief Roll On, Knee & Lower Back Pain Relief, Arthritis Pain Reliever, Neck Pain Relief, Cooling Joint Pain Relief, Roll-On Menthol Gel 3 Fl Oz (Pack of 3)
Biofreeze Professional Pain Relief Roll On, Knee & Lower Back Pain Relief, Arthritis Pain Reliever, Neck Pain Relief, Cooling Joint Pain Relief, Roll-On Menthol Gel 3 Fl Oz (Pack of 3)
Active Ingredients: Menthol
Type of Pain: Backaches, strains, bruises, sprains, arthritis
Scent: Menthol
Skin Sensitivity: Menthol can be irritating
Application Method: Roll-On
Chosen by 1108 this week
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief - NEW Easy Open Cap - 150 g
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief - NEW Easy Open Cap - 150 g
Active Ingredients: NSAID
Type of Pain: arthritis pain
Scent: clean
Skin Sensitivity: paraben and dye-free
Application Method: apply 4 times daily
Biofreeze Pain Relief Cream, Knee & Lower Back Pain Relief, Sore Muscle Relief, Neck Pain Relief, Shoulder Pain Relief, Muscle Recovery, FSA Eligible, 3 OZ Biofreeze Menthol Cream
Biofreeze Pain Relief Cream, Knee & Lower Back Pain Relief, Sore Muscle Relief, Neck Pain Relief, Shoulder Pain Relief, Muscle Recovery, FSA Eligible, 3 OZ Biofreeze Menthol Cream
Active Ingredients: Menthol
Type of Pain: Knee, back, muscles, neck, shoulder, arthritis
Absorption Rate: Fast-acting
Scent: Menthol
Skin Sensitivity: Suitable for dry or sensitive skin
Application Method: 3 oz. jar
Biofreeze Professional Gel Pain Relief, Knee & Lower Back Pain Relief, Arthritis Pain Reliever, Sore Muscle Relief, Neck Pain Relief, Cooling Joint Pain Relief, Colorless Menthol Gel 4 Fl Oz
Biofreeze Professional Gel Pain Relief, Knee & Lower Back Pain Relief, Arthritis Pain Reliever, Sore Muscle Relief, Neck Pain Relief, Cooling Joint Pain Relief, Colorless Menthol Gel 4 Fl Oz
Active Ingredients: USP grade menthol
Type of Pain: knee, lower back, arthritis, muscles
Absorption Rate: fast-acting
Skin Sensitivity: cooling sensation might be uncomfortable
Application Method: gel
Biofreeze Pain Relief Gel, Arthritis Pain Reliver, Knee & Lower Back Pain Relief, Sore Muscle Relief, Neck Pain Relief, Pharmacist Recommended, FSA Eligible, 3 FL OZ Biofreeze Menthol Gel
Biofreeze Pain Relief Gel, Arthritis Pain Reliver, Knee & Lower Back Pain Relief, Sore Muscle Relief, Neck Pain Relief, Pharmacist Recommended, FSA Eligible, 3 FL OZ Biofreeze Menthol Gel
Active Ingredients: USP grade menthol
Type of Pain: arthritis, knee, lower back, sore muscles, neck
Absorption Rate: fast-acting
Scent: strong menthol
Skin Sensitivity: suitable for sensitive skin
Application Method: gel
Related Products
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief, No Prescription Needed - 1.7 oz/50 g Tube
Voltaren Arthritis Pain Gel for Powerful Topical Arthritis Pain Relief, No Prescription Needed - 1.7 oz/50 g Tube
Active Ingredients: Diclofenac Sodium
Type of Pain: Arthritis pain
Scent: Clean scent
Skin Sensitivity: Paraben and dye-free
Application Method: Topical gel, up to 4 times
Sub Zero Cooling Pain Relief Gel, 3oz Roll-On - Joint Relief and Nerve Pain Relief Cream for Muscle Deep Pain Relief, Back Pain Relief Products
Sub Zero Cooling Pain Relief Gel, 3oz Roll-On - Joint Relief and Nerve Pain Relief Cream for Muscle Deep Pain Relief, Back Pain Relief Products
Active Ingredients: menthol, cat's claw herb
Type of Pain: joint pain, nerve pain, muscle soreness
Absorption Rate: fast-acting
Scent: strong menthol
Application Method: roll-on
Amazon Basic Care Arthritis Pain Relieving Gel, Diclofenac Sodium Topical Gel, 1% (NSAID), 5.29 Oz (150 Grams) (Packaging may vary)
Amazon Basic Care Arthritis Pain Relieving Gel, Diclofenac Sodium Topical Gel, 1% (NSAID), 5.29 Oz (150 Grams) (Packaging may vary)
Active Ingredients: diclofenac sodium 1%
Type of Pain: arthritis
Skin Sensitivity: sensitive skin
Application Method: apply up to 4 times daily
Aspercreme Odor Free Max Strength Lidocaine Pain Relief Liquid with Roll-On No Mess Applicator, 2.5 oz.
Aspercreme Odor Free Max Strength Lidocaine Pain Relief Liquid with Roll-On No Mess Applicator, 2.5 oz.
Active Ingredients: Lidocaine
Type of Pain: Muscle, joint, back pain
Absorption Rate: Dries quickly
Scent: Odor-free
Application Method: Roll-on
#10
7.4 score
Tiger Balm Pain Relieving Ointment, Sports Ultra, 50g – Professional Size – Sports Rub Ultra Strength – Relief for Hand Arthritis – Tiger Balm Ultra
Tiger Balm Pain Relieving Ointment, Sports Ultra, 50g – Professional Size – Sports Rub Ultra Strength – Relief for Hand Arthritis – Tiger Balm Ultra
Active Ingredients: camphor and menthol
Type of Pain: muscle, joint aches, arthritis, strains
Absorption Rate: fast
Scent: strong
Skin Sensitivity: may cause irritation
Application Method: rub onto affected area 3-4 times
How do we rank products for you?
Our technology thoroughly searches through the online shopping world, reviewing hundreds of sites. We then process and analyze this information, updating in real-time to bring you the latest top-rated products. This way, you always get the best and most current options available.
Buying Guide for the Best Pain Relief Creams
When choosing a pain relief cream, it's important to consider several factors to ensure you select the best product for your needs. Pain relief creams can vary widely in their ingredients, effectiveness, and suitability for different types of pain. Understanding the key specifications and how they relate to your specific needs will help you make an informed decision.Active IngredientsActive ingredients are the components in the cream that provide pain relief. Common active ingredients include menthol, capsaicin, lidocaine, and salicylates. Each of these works differently; for example, menthol provides a cooling sensation, capsaicin can reduce pain by affecting nerve cells, lidocaine numbs the area, and salicylates reduce inflammation. Choose an active ingredient based on the type of pain you are experiencing. For muscle pain, menthol or capsaicin might be effective, while lidocaine is often used for nerve pain.
Type of PainDifferent pain relief creams are formulated to target specific types of pain, such as muscle pain, joint pain, or nerve pain. Understanding the type of pain you are experiencing will help you select the most appropriate cream. For example, if you have arthritis, a cream designed for joint pain with anti-inflammatory properties might be best. For muscle soreness after exercise, a cream with menthol or camphor might be more suitable.
Absorption RateThe absorption rate refers to how quickly the cream is absorbed into the skin and starts to provide relief. Some creams are designed for fast absorption, providing quick relief, while others may take longer to absorb but offer longer-lasting effects. If you need immediate relief, look for a cream with a fast absorption rate. If you prefer sustained relief, a slower-absorbing cream might be more appropriate.
ScentThe scent of a pain relief cream can be an important factor, especially if you are sensitive to strong smells or plan to use the cream in public settings. Some creams have a strong medicinal or menthol scent, while others are unscented or have a mild fragrance. Consider your personal preference and any potential sensitivities when choosing a cream with a scent that you can tolerate.
Skin SensitivityIf you have sensitive skin or allergies, it's important to choose a pain relief cream that is hypoallergenic and free from harsh chemicals or irritants. Look for creams that are labeled as suitable for sensitive skin or have been dermatologically tested. If you are unsure, you can perform a patch test by applying a small amount of the cream to a small area of your skin to check for any adverse reactions before using it more broadly.
Application MethodPain relief creams come in various forms, including gels, lotions, and roll-ons. The application method can affect ease of use and convenience. Gels and lotions are typically applied with the hands, which can be messy, while roll-ons offer a more convenient and mess-free application. Consider how you prefer to apply the cream and choose a form that fits your lifestyle and needs.