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Cold Sore Creams

10 Best Cold Sore Creams 2025 in the United States

#1

Winner

9.8 score

Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count

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Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count

Mederma

9.8 score

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The Mederma Fever Blister Discreet Healing Patch is designed to offer an effective solution for those dealing with cold sores. One of its standout features is its ability to instantly conceal cold sores, allowing users to feel more confident in social situations. The patches utilize hydrocolloid gel technology, which not only hides the sore but also creates an environment conducive to faster healing. Each patch can provide protection for up to 12 hours, helping to safeguard the sore from further contamination and irritation, which is particularly beneficial during the early stages of a cold sore outbreak.

Customer Highlights

A summary of real customer reviews to highlight what shoppers are saying!
Onset of Action
The patches provide instant relief from symptoms like tingling and itching.
Formulation Type
Hydrocolloid patches significantly reduce healing time, often cutting it in half.
#2
9.6 score

Red Light Therapy,Cold Sores Treatment&Fever Blister, Infrared Light Therapy for Lips Mouth Nose Ear Knee Feet Hands Joint Muscle Nerve Pain Relief Red Light Therapy for Face with Removable Tip

Red Light Therapy,Cold Sores Treatment&Fever Blister, Infrared Light Therapy for Lips Mouth Nose Ear Knee Feet Hands Joint Muscle Nerve Pain Relief Red Light Therapy for Face with Removable Tip

LETOURWM

9.6 score

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This red light therapy device is designed to alleviate cold sores and various other conditions such as muscle stiffness, joint pain, and inflammation. It is multifunctional, featuring a detachable tip for both facial and body applications, making it versatile for treating cold sores on the lips as well as pain relief across different body parts.

Customer Highlights

A summary of real customer reviews to highlight what shoppers are saying!
Onset of Action
Exponentially decreased the healing time of a sore on my lip. It worked day-1 and I could see it beginning to heal the next morning.
#3
9.4 score

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

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Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

Abreva

9.4 score

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Abreva 10 Percent Docosanol Cold Sore Treatment is a popular choice for those dealing with fever blisters, effectively helping to shorten the healing time. Containing 10 percent docosanol, it's clinically proven to address the symptoms associated with cold sores, such as tingling, pain, burning, and itching, and can help heal them in as little as 2.5 days. This makes it a strong contender in the cold sore cream category, especially for people seeking quick relief and recovery.

Customer Highlights

A summary of real customer reviews to highlight what shoppers are saying!
Onset of Action
Worked overnight, transforming a 3-4 day cold sore into a healed area by morning.
Moisturizing Properties
Feels more like a fresh moisturizer than an ointment or lip balm, providing a pleasant application experience.

Top 10 Best Cold Sore Creams 2025 in the United States

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FemiClear

FemiClear, Multi-Symptom Relief - Formulated with All-Natural and Organic Ingredients - 0.25 Ounce Tube

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#1

Winner

9.8 score

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Mederma

Mederma Fever Blister Discreet Healing Patch - A Patch That Protects and Conceals Cold Sores - 15 Count

Active Ingredients: hydrocolloid gel
Application Frequency: up to 12 hours
Formulation Type: patch

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5% OFF

Chosen by 1207 this week

Sponsored

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FemiClear

FemiClear, Multi-Symptom Relief - Formulated with All-Natural and Organic Ingredients - 0.25 Ounce Tube

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#2

9.6 score

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LETOURWM

Red Light Therapy,Cold Sores Treatment&Fever Blister, Infrared Light Therapy for Lips Mouth Nose Ear Knee Feet Hands Joint Muscle Nerve Pain Relief Red Light Therapy for Face with Removable Tip

Formulation Type: Light therapy device

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#3

9.4 score

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Abreva

Abreva 10 Percent Docosanol Cold Sore Treatment, Treats Your Fever Blister in 2.5 Days - 0.07 oz Tube x 2

Active Ingredients: 10% docosanol
Onset of Action: 2.5 days
Formulation Type: cream

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13% OFF
#4

9.1 score

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Quantum

Quantum Health Lip Clear Lysine+ Cold Sore Treatment Soothe & Moisturize Mouth Sores - L-Lysine Menthol Calendula & Propolis Ointment - Transparent Fever Blister Healing Balm - 0.25 Oz (Pack of 2)

Active Ingredients: L-Lysine, Menthol, Calendula, Vitamin E, Propolis, tea_tree_oil
Onset of Action: fast-acting
Moisturizing Properties: deep moisturization
Formulation Type: ointment

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25% OFF
#5

8.8 score

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Burt's Bees

Burt's Bees Cold Sore Treatment and Medicated Lip Balm, College Back to School Dorm Essentials, With Menthol and Eucalyptus Oil, Natural Origin Skincare, 2 Tubes, 0.07 oz./0.15 oz.

Active Ingredients: menthol, eucalyptus oil, jojoba oil
Application Frequency: 3-4 times daily
Moisturizing Properties: natural moisturizing oils
Formulation Type: natural, free from parabens

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#6

8.5 score

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Herpecin-L

Herpecin-L Pain Relief Triple Action with Lidocaine Cold Sore and Fever Blister Treatment, 0.15 oz

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27% OFF
#7

8.2 score

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TARO

TARO Cold Sore/Fever Blister Treatment - Docosanol 10% Cream (0.07 oz - 2 Tube)

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#8

8.0 score

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Abreva

Abreva Cold Sore Treatment Rapid Pain Relief Cream - 1 Tube, 3 Grams

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23% OFF
#9

7.7 score

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Releev

Releev 1 Day Cold Sore Treatment 6ML

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#10

7.4 score

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Orajel

Orajel Touch Free Cold Sore Treatment .12oz, Liquid Formula, Provides Immediate & Targeted Pain Relief, Bonus Size, 6 Applicators.

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11% OFF
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Buying Guide for the Best Cold Sore Creams

When choosing a cold sore cream, it's important to understand the key factors that can help you find the most effective product for your needs. Cold sore creams are designed to alleviate symptoms, speed up healing, and prevent the spread of the virus. By considering the following key specifications, you can make an informed decision and select the best cold sore cream for you.
Active IngredientsThe active ingredients in a cold sore cream are the components that help to treat the infection and alleviate symptoms. Common active ingredients include antiviral agents like acyclovir or docosanol, which help to reduce the duration and severity of cold sores. When choosing a cream, look for one with proven antiviral ingredients. If you have sensitive skin, you may want to opt for a product with natural ingredients like lysine or lemon balm extract. Your specific needs, such as the severity of your cold sores and any skin sensitivities, should guide your choice.
Application FrequencyApplication frequency refers to how often you need to apply the cream to achieve the best results. Some creams require application every few hours, while others may only need to be applied a couple of times a day. If you have a busy schedule, you might prefer a cream that requires less frequent application. However, if you are dealing with a particularly severe outbreak, a cream that needs to be applied more often might be more effective. Consider your daily routine and the severity of your symptoms when deciding on the right application frequency for you.
Onset of ActionOnset of action is the time it takes for the cream to start working after application. Some creams provide relief within a few hours, while others may take a day or two to show noticeable effects. If you need quick relief from pain and discomfort, look for a cream with a fast onset of action. For those who experience frequent cold sores, a cream with a quicker onset might be more beneficial to stop the outbreak in its early stages. Your need for immediate relief versus long-term management should guide your choice here.
Moisturizing PropertiesMoisturizing properties are important because cold sores can cause the skin to become dry and cracked, leading to further discomfort. Some cold sore creams contain moisturizing agents like aloe vera or vitamin E to help soothe and hydrate the affected area. If you have dry or sensitive skin, choosing a cream with added moisturizers can provide additional comfort and aid in the healing process. Consider your skin type and the level of dryness you experience when selecting a cream with the right moisturizing properties.
Formulation TypeCold sore creams come in various formulations, including gels, ointments, and lip balms. Gels and ointments are typically more potent and may be better suited for severe outbreaks, while lip balms are often more convenient for daily use and prevention. If you prefer a non-greasy feel, a gel might be the best option. For those who want a product that can be easily carried and applied on the go, a lip balm formulation could be ideal. Your preference for texture and convenience should help you decide on the right formulation type.

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